Protein Biophysics

Protein assembly and dysfunction are important for many processes vital to life. When protein misfolds or aggregates in the body, the consequences can be deadly. During my master's, I investigated how fluid flow contributes to formation of amyloid fibrils, which are highly ordered protein aggregates that contribute to Alzheimer's and Parkinson's Diseases. I am currently working on protein crystallization at interfaces. 

Publications

  1. McBride, S.A., Sanford, S.P., Lopez, J.M, Hirsa, A. “Shear-Induced Amyloid Fibrillization: the role of Inertia” Submitted, 2016

  2. McBride, S.A., Tilger, C., Sanford, S., Tessier, P., Hirsa, A. “Comparison of Human and Bovine Insulin Fibrillization under Uniform Shear” Journal of Physical Chemistry B, Aug 2015

 

Relevant Coursework

  • Physical Chemistry (U)

  • Thermodynamics (U)

  • Chemical Engineering Thermodynamics (G)

  • Single Particle in a Complex Fluid (G)

  • Transport Phenomena (G)

  • Colloidal and Interfacial Science (G)

  • Crystallization Science (G)

  • Fields, Forces, and Flows in Biological Systems (G)